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Junctophilin 1 antibody (C-Term)

JPH1 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500094
  • Target See all Junctophilin 1 (JPH1) Antibodies
    Junctophilin 1 (JPH1)
    Binding Specificity
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 15
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 12
    • 3
    Rabbit
    Clonality
    • 13
    • 2
    Polyclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    This Junctophilin 1 antibody is un-conjugated
    Application
    • 10
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects JPH1.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    JPH1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human JPH1.
    Isotype
    IgG
    Top Product
    Discover our top product JPH1 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    Junctophilin 1 (JPH1)
    Abstract
    JPH1 Products
    Synonyms
    JP-1 antibody, JP1 antibody, ENSMUSG00000054314 antibody, Jp1 antibody, bZ1M12.3 antibody, jph1 antibody, si:rp71-1m12.3 antibody, Jph1 antibody, junctophilin 1 antibody, junctophilin 1a antibody, junctophilin-1 antibody, JPH1 antibody, Jph1 antibody, jph1 antibody, jph1a antibody, LOC100547979 antibody
    Background
    Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH1 is essential for stabilizing the T-tubule and SR membranes to form junctions and provide an environment for the assembly of receptors such as the ryanodine receptor type 1 (RyR1).Synonyms: JP1
    Gene ID
    56704
    NCBI Accession
    NP_065698
    UniProt
    Q9HDC5
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