SLC6A8 antibody (Internal Region)

Catalog No. ABIN954829

Product Details anti-SLC6A8 Antibody

Target: SLC6A8 (Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This SLC6A8 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: ASLANLTCDQ LADRR

Specificity: This antibody is expected to recognize all reported isoforms (NP_005620.1, NP_001136277.1, NP_001136278.1).

Cross-Reactivity (Details): Species reactivity (expected):Human, Rat, Dog, Pig, Cow.
Species reactivity (tested):Mouse.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_005620.1, NP_001136277.1, NP_001136278.1. Genename: SLC6A8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SLC6A8

Target: SLC6A8 (Solute Carrier Family 6 (Neurotransmitter Transporter, Creatine), Member 8 (SLC6A8))

Alternative Name: SLC6A8 (SLC6A8 Products)

Synonyms: SLC6A8 antibody, chot1 antibody, crtr antibody, creaT antibody, CHOT1 antibody, CHT1 antibody, CRT antibody, CT1 antibody, AA589632 antibody, CRTR antibody, Creat antibody, CCDS1 antibody, solute carrier family 6 member 8 antibody, sodium- and chloride-dependent creatine transporter 1 antibody, solute carrier family 6 (neurotransmitter transporter), member 8 antibody, solute carrier family 6 (neurotransmitter transporter, creatine), member 8 antibody, SLC6A8 antibody, LOC473853 antibody, slc6a8 antibody, LOC100440816 antibody, Slc6a8 antibody

Background: Creatine and creatine phosphate are essential for the maintenance of ATP levels in tissues with high and fluctuating energy demands such as skeletal muscle and brain. Creatine kinase catalyzes the reversible transfer of a phosphate from creatine phosphate to ADP regenerating ATP. In mammals, creatine is either synthesized by sequential reactions occurring in the kidney and liver or obtained from the diet. Muscle cells do not synthesize creatine, but take it up via a special sodium-dependent transporter, the creatine transporter (CRT). Inhibition of creatine transport in experimental animals causes muscle weakness. A specific uptake system for creatine has been demonstrated in skeletal muscle, human monocytes, macrophages, and astroglial-rich cultures. CRT exhibits significant homology to the Na(+) and Cl(-) dependent GABA/norepinephrine (GAT-1/norepinephrine transporter) gene family of neurotransmitter transporters. All members of this family are predicted to contain 12-membrane-spanning domains, to contain a large extracellular loop containing sites for N-linked glycosylation between the third and fourth transmembrane domains, and to have the amino and carboxyl termini facing the cytoplasmic side of the membrane. At least two CRT have been cloned and expressed and characterized. CRT1 or CT1 (mouse, human 635 aa, chromosome X28) is expressed in kidney, muscle, brain, and other tissues, while CT2 (human 426-aa, chromosome 16p11.2) is testis specific.Synonyms: CT1, Creatine transporter 1, Sodium- and chloride-dependent creatine transporter 1, Solute carrier family 6 member 8

Gene ID: 6535

NCBI Accession: NP_001136277

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response