Periostin antibody (full length)
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- Target See all Periostin (POSTN) Antibodies
- Periostin (POSTN)
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Binding Specificity
- full length
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Reactivity
- Human, Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Periostin antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Specificity
- Recognizes human and mouse periostin.
- Cross-Reactivity
- Human, Mouse (Murine)
- Purity
- >95 % (SDS-PAGE)
- Immunogen
- Full-length human periostin.
- Clone
- Stiny-1
- Isotype
- IgG1
- Top Product
- Discover our top product POSTN Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- In PBS containing 10 % glycerol.
- Preservative
- Without preservative
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - Expiry Date
- 12 months
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- Target
- Periostin (POSTN)
- Alternative Name
- Periostin (POSTN Products)
- Synonyms
- fa99h07 antibody, pn antibody, postn antibody, wu:fa99h07 antibody, wu:fc70f09 antibody, zgc:153873 antibody, LOC100008945 antibody, osf-2 antibody, pdlpostn antibody, periostin antibody, OSF-2 antibody, OSF2 antibody, PDLPOSTN antibody, PN antibody, RP11-412K4.1 antibody, A630052E07Rik antibody, AI747096 antibody, Osf2 antibody, PLF antibody, peri antibody, Plf antibody, periostin antibody, periostin, osteoblast specific factor b antibody, periostin, osteoblast specific factor antibody, POSTN antibody, postnb antibody, postn antibody, Postn antibody
- Background
- Periostin is a 90- kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.
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