ATF4
Reactivity: Human
WB
Host: Rabbit
Polyclonal
RB10931
unconjugated
Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Buffer
In 1x PBS, pH 7.4
Handling Advice
Aliquot to avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Ghemrawi, Pooya, Lorentz, Gauchotte, Arnold, Gueant, Battaglia-Hsu: "Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1." in: Cell death & disease, Vol. 4, pp. e553, (2013) (PubMed).
Wang, Wang, Zhang, Qu, Liu: "A protective role of heme-regulated eIF2? kinase in cadmium-induced toxicity in erythroid cells." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 62, pp. 880-91, (2013) (PubMed).
Cole, Kuhn, Green-Mitchell, Leone, Raab, Nadler, Chakrabarti: "12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response." in: American journal of physiology. Endocrinology and metabolism, Vol. 302, Issue 6, pp. E654-65, (2012) (PubMed).
Suragani, Zachariah, Velazquez, Liu, Sun, Townes, Chen: "Heme-regulated eIF2? kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis." in: Blood, Vol. 119, Issue 22, pp. 5276-84, (2012) (PubMed).
Meister, Frey, Lang, Gaipl, Schett, Schlötzer-Schrehardt, Voll: "Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells." in: Neoplasia (New York, N.Y.), Vol. 12, Issue 7, pp. 550-61, (2010) (PubMed).
Target
ATF4
(Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))