STT3A antibody (AA 476-507)

Catalog No. ABIN5647816

Product Details anti-STT3A Antibody

Target: STT3A (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog A (STT3A))

Binding Specificity: AA 476-507

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STT3A antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity (Details): Expected species reactivity: Mouse,Bovine

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 476-507 from the human protein was used as the immunogen for the STT3A antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Western blot: 1:1000-2000

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the STT3A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for STT3A

Target: STT3A (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog A (STT3A))

Alternative Name: STT3A (STT3A Products)

Synonyms: cb437 antibody, wu:fb38c11 antibody, AA408947 antibody, BB081708 antibody, Itm1 antibody, ITM1 antibody, STT3-A antibody, TMC antibody, STT3A, subunit of the oligosaccharyltransferase complex (catalytic) antibody, STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) antibody, STT3A, catalytic subunit of the oligosaccharyltransferase complex antibody, stt3a antibody, Stt3a antibody, STT3A antibody

Background: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A is the catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.

Gene ID: 3703

UniProt: P46977