SLC5A8 antibody (AA 579-609)

Catalog No. ABIN5647944

Product Details anti-SLC5A8 Antibody

Target: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Binding Specificity: AA 579-609

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC5A8 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 579-609 from the human protein was used as the immunogen for the SLC5A8 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Western blot: 1:500-1000

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SLC5A8 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for SLC5A8

Target: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Alternative Name: SLC5A8 / Sodium-coupled monocarboxylate transporter 1 (SLC5A8 Products)

Synonyms: Ait antibody, SMCT antibody, SMCT1 antibody, AIT antibody, RGD1564146 antibody, solute carrier family 5 (iodide transporter), member 8 antibody, solute carrier family 5 member 8 antibody, Slc5a8 antibody, SLC5A8 antibody

Background: Solute carrier family 5 member 8 acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Gene ID: 160728

UniProt: Q8N695