YES1 antibody

Catalog No. ABIN5647984

Product Details anti-YES1 Antibody

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This YES1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: Human recombinant protein was used as the immunogen for this YES1 antibody.

Clone: 1612CT505-7-50

Isotype: IgG1 kappa

Application Details

Application Notes: Western blot: 1:2000-4000

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the YES1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for YES1

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Alternative Name: YES (YES1 Products)

Synonyms: HsT441 antibody, P61-YES antibody, Yes antibody, c-yes antibody, yes antibody, p61-Yes antibody, hst441 antibody, p61-yes antibody, YES antibody, c-Yes antibody, p60c-yes antibody, YES proto-oncogene 1, Src family tyrosine kinase antibody, YES proto-oncogene 1, Src family tyrosine kinase L homeolog antibody, YES1 antibody, yes1.L antibody, yes1 antibody, Yes1 antibody

Background: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Gene ID: 7525

UniProt: P07947

Pathways: CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling