UQCRC1 antibody (AA 156-480)

Catalog No. ABIN1683221

Product Details anti-UQCRC1 Antibody

Target: UQCRC1 (Ubiquinol-Cytochrome C Reductase Core Protein I (UQCRC1))

Binding Specificity: AA 156-480

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UQCRC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: LEDSQIEKER DVILREMQEN DASMRDVVFN YLHATAFQGT PLAQAVEGPS ENVRKLSRAD LTEYLSTHYK APRMVLAAAG GVEHQQLLDL AQKHLGGIPW TYAEDAVPTL TPCRFTGSEI RHRDDALPFA HVAIAVEGPG WASPDNVALQ VANAIIGHYD CTYGGGVHLS SPLASGAVAN KLCQSFQTFS ICYAETGLLG AHFVCDRMKI DDMMFVLQGQ WMRLCTSATE SEVARGKNIL RNALVSHLDG TTPVCEDIGR SLLTYGRRIP LAEWESRIAE VDASVVREIC SKYIYDQCPA VAGYGPIEQL PDYNRIRSGM FWLRF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 156-480 of human UQCRC1 (NP_003356.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UQCRC1

Target: UQCRC1 (Ubiquinol-Cytochrome C Reductase Core Protein I (UQCRC1))

Alternative Name: UQCRC1 (UQCRC1 Products)

Synonyms: MGC53748 antibody, zgc:73404 antibody, zgc:85750 antibody, 1110032G10Rik antibody, D3S3191 antibody, QCR1 antibody, UQCR1 antibody, ubiquinol-cytochrome c reductase core protein 1 L homeolog antibody, ubiquinol-cytochrome c reductase core protein 1 antibody, ubiquinol-cytochrome c reductase core protein I antibody, cytochrome b-c1 complex subunit 1, mitochondrial antibody, uqcrc1.L antibody, uqcrc1 antibody, UQCRC1 antibody, LOC100020379 antibody, LOC100074417 antibody, LOC100347571 antibody, LOC100413740 antibody, LOC100452425 antibody, Uqcrc1 antibody

Background: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII, ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII and cytochrome c oxidase (complex IV, CIV, that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity. The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS/subunit 9 when incorporated into complex III (Probable.,UQCRC1,D3S3191,QCR1,UQCR1,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Cytochromes,Mitochondrial markers,Oxidative phosphorylation,Neuroscience,Neurodegenerative Diseases,UQCRC1

Molecular Weight: 52 kDa

Gene ID: 7384

UniProt: P31930