TNFRSF11A antibody (AA 30-212)

Catalog No. ABIN5684101

Product Details anti-TNFRSF11A Antibody

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Binding Specificity: AA 30-212

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF11A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)

Purification: purified

Immunogen: Purified recombinant fragment of human TNFRSF11A (AA: extra 30-212) expressed in E. coli.

Clone: 1B5D10

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for TNFRSF11A

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Alternative Name: TNFRSF11A (TNFRSF11A Products)

Synonyms: RANK antibody, RGD1563614 antibody, TNFRSF11A antibody, Ly109 antibody, ODFR antibody, OFE antibody, Rank antibody, TRANCE-R antibody, mRANK antibody, CD265 antibody, FEO antibody, LOH18CR1 antibody, OPTB7 antibody, OSTS antibody, PDB2 antibody, TRANCER antibody, TNF receptor superfamily member 11A antibody, TNF receptor superfamily member 11a antibody, tumor necrosis factor receptor superfamily, member 11a, NFKB activator antibody, Tnfrsf11a antibody, TNFRSF11A antibody

Background:

Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

Aliases: FEO, OFE, ODFR, OSTS, PDB2, RANK, CD265, OPTB7, TRANCER, LOH18CR1

Molecular Weight: 66 kDa

Gene ID: 8792

HGNC: 353514

Pathways: NF-kappaB Signaling