SPINT2 antibody (Internal Region)

Catalog No. ABIN568704

Product Details anti-SPINT2 Antibody

Target: SPINT2 (serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))

Binding Specificity: Internal Region

Reactivity: Human, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This SPINT2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-PSAPRRQDSE DH

Specificity: This antibody is expected to recognize both reported isoforms (NP_066925.1, NP_001159575.1).

Cross-Reactivity (Details): Species reactivity (expected):Dog, Cow.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_066925.1 and NP_001159575.1. Genename: SPINT2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SPINT2

Target: SPINT2 (serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))

Alternative Name: SPINT2 / HAI2 (SPINT2 Products)

Synonyms: HAI-2 antibody, Pb antibody, DIAR3 antibody, HAI2 antibody, Kop antibody, PB antibody, AL024025 antibody, C76321 antibody, serine peptidase inhibitor, Kunitz type, 2 antibody, serine peptidase inhibitor, Kunitz type 2 antibody, serine protease inhibitor, Kunitz type 2 antibody, Spint2 antibody, SPINT2 antibody

Background: HAI-2 (SPINT2) is a candidate tumour suppressor gene that is frequently hypermethylated and underexpressed in Human HCCs, and the KD-1 domain of HAI-2 is the key region responsible for its anti-invasive function. It is also implicated in Human cervical cancer. SPINT2 is an inhibitor of HGF activator. SPINT2 also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.Synonyms: HAI-2, Hepatocyte growth factor activator inhibitor type 2, Kunitz-type protease inhibitor 2, Placental bikunin

Gene ID: 10653

NCBI Accession: NP_066925

UniProt: O43291