Ubiquitin hydrolase 1 antibody

Catalog No. ABIN5688748

Product Details

Target: Ubiquitin hydrolase 1

Reactivity: Human, Cow, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for the ~24  kDa UCHL1 protein.

Purification: Total IgG fraction

Immunogen: Recombinant full length human UCHL1 purified from E. coli.

Clone: MCA-BH7

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Storage Comment: Ubiquitin Hydrolase 1 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Target Details

Target: Ubiquitin hydrolase 1

Background: Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.

Molecular Weight: 24 kDa

Gene ID: 7345

UniProt: P09936