CTRP6 antibody (Globular Domain)

Catalog No. ABIN5688783

Product Details anti-CTRP6 Antibody

Target: CTRP6 (C1QTNF6) (Complement C1q Tumor Necrosis Factor-Related Protein 6 (C1QTNF6))

Binding Specificity: Globular Domain

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTRP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Recognizes the N-terminal half of human CTRP6 full-length protein. Detects bands of ~16  kDa and ~32  kDa by Western blot.

Immunogen: Recombinant human CTRP6 (globular domain-less).

Clone: 256-E

Isotype: IgG1 kappa

Application Details

Application Notes: ELISA: (direct or indirect: 1:200-1:500). Immunohistochemistry (paraffin sections): 1:200. Western blot: (1:200-1:500 using ECL. Suggested blocking and dilution buffer is PBST with 0.05 % Tween 20 and 5 % skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions should be determined individually for each application.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. 0.2um-filtered solution in PBS,  pH 7.4. Contains no preservatives.

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Stable for at least 1 year after receipt when stored at -20°C.

Target Details for CTRP6

Target: CTRP6 (C1QTNF6) (Complement C1q Tumor Necrosis Factor-Related Protein 6 (C1QTNF6))

Alternative Name: CTRP6 (C1QTNF6 Products)

Synonyms: MGC148634 antibody, CTFP6 antibody, CTRP6 antibody, ZACRP6 antibody, 2810036M19Rik antibody, Ctrp6 antibody, C1q and TNF related 6 antibody, C1q and tumor necrosis factor related protein 6 antibody, C1QTNF6 antibody, C1qtnf6 antibody

Background: CTRP6 mediates the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in skeletal muscle cells, subsequently mediating glycogen accumulation and fatty acid oxidation. It induces the expression of the potent anti-inflammatory cytokine IL-10 in macrophages. CTRP6 may be a potential serum marker for hepatocellular carcinoma, contributing to tumor angiogenesis by activating the Akt pathway. CTRP6 was also shown to be associated with obesity, type 1 diabetes mellitus (T1D), vitiligo (depigmentation of the skin) and ASFV (African Swine Fever Virus). CTRP6 forms homotrimers and higher-order oligomers and it may also form heteromeric complexes with CTRP1. May be involved in kidney inflammation.

Gene ID: 114904

UniProt: Q9BXI9