GRIN2B antibody (C-Term)

Catalog No. ABIN5688852

This Rabbit Polyclonal antibody specifically detects GRIN2B in WB, IHC and IP. It exhibits reactivity toward Human and Rat.

Quick Overview for GRIN2B antibody (C-Term) (ABIN5688852)

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIN2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-GRIN2B Antibody

Binding Specificity: C-Term

Purification: Affinity Purified

Immunogen: NMDA NR2B polyclonal antibody was raised against a C-terminal fusion protein of the NR2B subunit of the NMDAR.

Application Details

Application Notes: NMDA NR2B Subunit antibody is specific for the 180 kDa NR2B subunit in Western blots of most brain regions. Immunolabeling blocked by pre-adsorption of antibody with the C-terminal fusion protein of the NR2B subunit that was used to generate the antibody. No reactivity towards the NR2A subunit of the NMDAR. Applications include Dot Blots (DB), Immunohistochemistry (IHC), Immunoprecipitation (IP) and Western Blots (WB). Immunolabeling has been demonstrated in human, mouse and rat tissues. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB, 1:1000-1:2000 for IHC, and in IP, 3 μ,g/200 μ,g lysate will quantitatively precipitate all NMDAR 2B.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Storage: -20 °C

Storage Comment: NMDA NR2B Subunit antibody can be stored at -20°C. After reconstitution in 50 μ,l PBS, the antibody should be aliquot and stored at -20°C and is stable at -20°C for at least 1 year. Ambient shipment is suitable for both international and domestic.

Target Details for GRIN2B

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Alternative Name: NMDA NR2B

Background: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression.

Molecular Weight: 180 kDa

Gene ID: 24410

UniProt: Q00960

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity