PLK1 antibody (pThr210)
Quick Overview for PLK1 antibody (pThr210) (ABIN5688913)
Target
See all PLK1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- pThr210
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Purification
- Affinity Purified
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Immunogen
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr210 of PLK1.
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Application Notes
- The antibody has been directly tested for reactivity in Western blots in rat and human tissues. It is anticipated that the antibody will react with bovine, canine, mouse, non-human primate, Xenopus and Zebrafish tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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Storage
- -20 °C
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Storage Comment
- PLK1 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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- PLK1 (Polo-Like Kinase 1 (PLK1))
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Alternative Name
- PLK1
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Background
- Polo-like kinases are important regulators of cell cycle progression. PLK1 is a highly conserved Ser/Thr kinase that has essential roles in the formation of mitotic bipolar spindles (van Vugt et al., 2004). Deregulated expression of PLK's is detected in many types of cancer and associated with oncogenesis (Takei et al., 2005). It has been proposed that PLK1 function is altered at different stages of mitosis through consecutive phosphorylation events at Ser137 and Thr210 (van de Weerdt et al., 2005).
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Molecular Weight
- 66 kDa
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Gene ID
- 5347
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UniProt
- P53350
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Pathways
- Cell Division Cycle, M Phase
Target
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