LPP antibody (AA 1-109)

Catalog No. ABIN5689866

Product Details anti-LPP Antibody

Target: LPP (Lipoma-preferred partner (LPP))

Binding Specificity: AA 1-109

Reactivity: Human, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LPP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Specificity: Recognizes human, rat and pig LPP.

Purification: Antigen affinity purified.

Immunogen: Recombinant human lipoma preferred partner (LPP) (aa 1-109).

Application Details

Application Notes: Immunocytochemistry: (1:500). Immunohistochemistry: (1:500). Western Blot: (1:1,000) . Optimal conditions must be determined individually for each application.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 500 μg/mL

Buffer: Liquid. In PBS containing 0.01 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for at least 1 year after receipt when stored at -20°C.

Target Details for LPP

Target: LPP (Lipoma-preferred partner (LPP))

Alternative Name: Lipoma Preferred Partner (LPP Products)

Synonyms: 9430020K16Rik antibody, AA959454 antibody, AU024130 antibody, B130055L10Rik antibody, C79715 antibody, D630048H16 antibody, LIM domain containing preferred translocation partner in lipoma antibody, LPP antibody, Lpp antibody

Background: Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.

Gene ID: 4026

NCBI Accession: NP_001161143

UniProt: Q93052