SNRPE antibody (AA 330-380)

Catalog No. ABIN5689894

Product Details anti-SNRPE Antibody

Target: SNRPE (Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE))

Binding Specificity: AA 330-380

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNRPE antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: At least two isoforms of B-raf are known to exist, this antibody will detect both isoforms. This antibody will not cross-react with C-raf.

Purification: B-raf Antibody is affinity chromatography purified via peptide column.

Immunogen: B-raf antibody was raised against a 19 amino acid peptide near the center of human B-raf.

The immunogen is located within amino acids 330 - 380 of B-raf.

Isotype: IgG

Application Details

Application Notes: B-raf antibody can be used for detection of B-raf by Western blot at 1 and 2 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: B-raf Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: B-raf antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for SNRPE

Target: SNRPE (Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE))

Alternative Name: B-raf (SNRPE Products)

Synonyms: B-raf antibody, HYPT11 antibody, SME antibody, Sm-E antibody, b-raf antibody, sm-e antibody, sme antibody, SmE antibody, snRNP-E antibody, AL022645 antibody, C76690 antibody, zgc:56682 antibody, small nuclear ribonucleoprotein polypeptide E antibody, small nuclear ribonucleoprotein polypeptide E L homeolog antibody, small nuclear ribonucleoprotein E antibody, SNRPE antibody, snrpe.L antibody, Snrpe antibody, snrpe antibody

Background: B-raf Antibody: B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. The Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt pathways interact with each other to regulate growth and in some cases tumorigenesis. Mutations in B-raf have been associated with several cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung, leading to speculation on the possibility of B-raf as a therapeutic target for treating cancers. Mutations in this gene have also been associated with cardiofaciocutaneous syndrome (CFCS), a disease characterized by heart defects, mental retardation and a distinctive facial appearance.

Molecular Weight: Predicted: 84

Observed: 99, multiple post-translational modifications, commonly observed at 95-100kDa

Gene ID: 673

UniProt: P15056

Pathways: Ribonucleoprotein Complex Subunit Organization, Hepatitis C