CISD2 antibody (AA 40-90)

Catalog No. ABIN5689926

This Rabbit Polyclonal antibody specifically detects CISD2 in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CISD2 antibody (AA 40-90) (ABIN5689926)

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CISD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CISD2 Antibody

Binding Specificity: AA 40-90

Purification: CISD2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.

The immunogen is located within amino acids 40 - 90 of CISD2.

Isotype: IgG

Application Details

Application Notes: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CISD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: CISD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for CISD2

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Alternative Name: CISD2

Background: CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Molecular Weight: Predicted: 15 kDa

Observed: 15 kDa

Gene ID: 493856

NCBI Accession: NP_001008389

UniProt: Q8N5K1

Pathways: Activation of Innate immune Response