CTHRC1 antibody is human, mouse and rat reactive. At least two isoforms of CTHRC1 are known to exist, this antibody will detect only the larger isoform.
Purification
CTHRC1 antibody is affinity chromatography purified via peptide column.
Immunogen
CTHRC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CTHRC1.
The immunogen is located within the first 50 amino acids of CTHRC1.
CTHRC1
Reactivity: Human
ELISA
Host: Rabbit
Polyclonal
Biotin
Application Notes
CTHRC1 antibody can be used for detection of CTHRC1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
CTHRC1 antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
CTHRC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration (1). CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells (2). CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer (3). Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma (4).