PTPN5 antibody (AA 180-230)

Catalog No. ABIN5690111

Product Details anti-PTPN5 Antibody

Target: PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))

Binding Specificity: AA 180-230

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: PTPN5 antibody is human and mouse reactive.

Purification: PTPN5 antibody is affinity chromatography purified via peptide column.

Immunogen: PTPN5 antibody was raised against an 18 amino acid peptide near the amino terminus of human PTPN5.

The immunogen is located within amino acids 180 - 230 of PTPN5.

Isotype: IgG

Application Details

Application Notes: PTPN5 antibody can be used for detection of PTPN5 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PTPN5 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: PTPN5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for PTPN5

Target: PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))

Alternative Name: PTPN5 (PTPN5 Products)

Synonyms: STEP antibody, Step antibody, PTPSTEP antibody, protein tyrosine phosphatase, non-receptor type 5 antibody, ptpn5 antibody, PTPN5 antibody, Ptpn5 antibody

Background: The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1). It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2). NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5). PTPN5 may play a role in Alzheimer's disease (1).

Molecular Weight: Predicted: 62 kDa

Observed: 60 kDa

Gene ID: 84867

NCBI Accession: NP_008837

UniProt: Q86TL6