TRIM33 antibody (AA 580-630)

Catalog No. ABIN5690302

Product Details anti-TRIM33 Antibody

Target: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Binding Specificity: AA 580-630

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM33 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: TRIM33 antibody is human, mouse and rat reactive. At least two isoforms of TRIM33 are known to exist.

Purification: TRIM33 Antibody is affinity chromatography purified via peptide column.

Immunogen: TRIM33 antibody was raised against an 18 amino acid peptide near the center of human TRIM33.

The immunogen is located within amino acids 580 - 630 of TRIM33.

Isotype: IgG

Application Details

Application Notes: TRIM33 antibody can be used for detection of TRIM33 by Western blot at 1 - 2 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TRIM33 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: TRIM33 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for TRIM33

Target: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Alternative Name: TRIM33 (TRIM33 Products)

Synonyms: TRIM33 antibody, ptc7 antibody, rfg7 antibody, tf1g antibody, tif1g antibody, tifgamma antibody, MGC146665 antibody, tif1gamma antibody, ECTO antibody, PTC7 antibody, RFG7 antibody, TF1G antibody, TIF1G antibody, TIF1GAMMA antibody, TIFGAMMA antibody, ecto antibody, 8030451N04Rik antibody, AI413936 antibody, Ecto antibody, Tif1g antibody, ectodermin antibody, mKIAA1113 antibody, cb1085 antibody, id:ibd2175 antibody, mon antibody, wu:fc17f10 antibody, zgc:136680 antibody, tripartite motif containing 33 antibody, tripartite motif containing 33 L homeolog antibody, tripartite motif-containing 33 antibody, TRIM33 antibody, trim33 antibody, trim33.L antibody, Trim33 antibody

Background: TRIM33 Antibody: TRIM24 (TIF1alpha), TRIM28 (TIF1beta), and TRIM33 (TIF1gamma) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors (1-2). The structure of TRIM33 is similar to TRIM24 and TRIM28, exhibiting multiple domains (RING finger, coiled coil, B boxes, PHD/TTC, and bromodomain) (3). TRIM33 functions in cell differentiation and development, playing a role in differentiation of hematopoietic cells (3). It interacts with the Smad2/3 transcription factor in hematopoietic, mesenchymal, and epithelial cell types to mediate different transcriptional effects in response to TGF-beta (4). It acts as an E3 ubiquitin-protein ligase and promotes SMAD4 ubiquitination (5).

Molecular Weight: Predicted: 70, 124 kDa

Observed: 70 kDa

Gene ID: 51592

NCBI Accession: NP_056990

UniProt: Q9UPN9