Bestrophin 1 antibody (DyLight 488)
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- Target See all Bestrophin 1 (BEST1) Antibodies
- Bestrophin 1 (BEST1)
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Bestrophin 1 antibody is conjugated to DyLight 488
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Application
- Flow Cytometry (FACS)
- Sequence
- RFIYRLALTE EQQLMFEKLT LYCD
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
- Rabbit IgG Polyclonal Anti-Human Bestrophin Antibody DyLight® 488 Conjugated, Flow Validated.
- Immunogen
- A synthetic peptide corresponding to a sequence of human Bestrophin (RFIYRLALTEEQQLMFEKLTLYCD).
- Top Product
- Discover our top product BEST1 Primary Antibody
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- Application Notes
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Application Details: Flow Cytometry, 1-3 μg/1x106 cells
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- At 2-8°C for one year. Protect from light. Do not freeze.
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- Target
- Bestrophin 1 (BEST1)
- Alternative Name
- BEST1 (BEST1 Products)
- Synonyms
- CG6264 antibody, Dbest antibody, Dmel\\CG6264 antibody, anon-WO0118547.380 antibody, best antibody, dBest1 antibody, dbest1 antibody, dmBest1 antibody, BEST1 antibody, VMD2 antibody, best-1 antibody, ARB antibody, BEST antibody, BMD antibody, RP50 antibody, TU15B antibody, Bmd antibody, Vmd2 antibody, mBest1 antibody, Bestrophin 1 antibody, bestrophin 1 antibody, Best1 antibody, BEST1 antibody, best1 antibody, Bm1_25500 antibody
- Background
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Synonyms: Bestrophin-1, TU15B, Vitelliform macular dystrophy protein 2, BEST1, VMD2
Tissue Specificity: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.
Background: Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
- UniProt
- O76090
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