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TPMT antibody (AA 1-245)

TPMT Reactivity: Human, Mouse, Rat ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5693135
$315.00
Plus shipping costs $45.00
100 μg
Shipping to: United States
Delivery in 4 to 6 Business Days
  • Target See all TPMT Antibodies
    TPMT (Thiopurine S-Methyltransferase (TPMT))
    Binding Specificity
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-245
    Reactivity
    • 46
    • 11
    • 10
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 30
    • 10
    • 6
    Rabbit
    Clonality
    • 36
    • 10
    Polyclonal
    Conjugate
    • 23
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TPMT antibody is un-conjugated
    Application
    • 29
    • 23
    • 15
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for TPMT detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.
    Immunogen
    E. coli-derived human TPMT recombinant protein (Position: M1-K245).
  • Application Notes

    Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

    Application Details: Western blot, 0.1-0.5 μg/mL
    Direct ELISA, 0.1-0.5 μg/mL

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Target
    TPMT (Thiopurine S-Methyltransferase (TPMT))
    Alternative Name
    TPMT (TPMT Products)
    Synonyms
    MGC84277, AW106912, NHLRC1, thiopurine S-methyltransferase L homeolog, thiopurine S-methyltransferase, tandem duplicate 2, thiopurine S-methyltransferase TpmT, thiopurine S-methyltransferase, Thiopurine S-methyltransferase, thiopurine methyltransferase, tpmt.L, tpmt.2, tpmT, MCA0794, Pnap_4948, Hhal_1383, TK90_1044, Slit_1144, Tint_0842, Fbal_3334, Celly_3188, Weevi_1737, Psefu_2696, Metme_3860, Tpmt, TPMT
    Background

    Synonyms: Thiopurine S-methyltransferase, Thiopurine methyltransferase, TPMT

    Background: Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

    UniProt
    P51580
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