AFF4 antibody

Catalog No. ABIN5696888

Product Details anti-AFF4 Antibody

Target: AFF4 (AF4/FMR2 Family, Member 4 (AFF4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFF4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Immunogen: AF4/FMR2 family, member 4

Isotype: IgG

Application Details

Application Notes: WB :1:200-1:2000,IP:1:200-1:1000

Comment:

L02 cells were subjected to SDS PAGE followed by western blot with FNab00197(AFF4 antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for AFF4

Target: AFF4 (AF4/FMR2 Family, Member 4 (AFF4))

Alternative Name: AFF4 (AFF4 Products)

Synonyms: AFF4 antibody, RA_m002_jsmFBA6Br antibody, AF5Q31 antibody, MCEF antibody, Alf4 antibody, Laf4l antibody, AF4/FMR2 family member 4 L homeolog antibody, AF4/FMR2 family member 4 antibody, AF4/FMR2 family, member 4 antibody, aff4.L antibody, AFF4 antibody, aff4 antibody, Aff4 antibody

Background: Synonyms:AF4/FMR2 family member 4, AF4/FMR2 family, member 4, AF5Q31, AFF4, MCEF, Protein AF 5q31 Background:Key component of the super elongation complex(SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins(ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.

Molecular Weight: 127kDa,observed 150kDa

Gene ID: 27125

UniProt: Q9UHB7