AIRE antibody
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- Target See all AIRE Antibodies
- AIRE (Autoimmune Regulator (AIRE))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AIRE antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- autoimmune regulator
- Isotype
- IgG
- Top Product
- Discover our top product AIRE Primary Antibody
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- Application Notes
- WB :1:500-1:5000,IHC:1:20-200
- Comment
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L02 cells were subjected to SDS PAGE followed by western blot with FNab00241( AIRE Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- AIRE (Autoimmune Regulator (AIRE))
- Alternative Name
- AIRE (AIRE Products)
- Synonyms
- AIRE1 antibody, APECED antibody, APS1 antibody, APSI antibody, PGA1 antibody, autoimmune regulator antibody, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) antibody, AaeL_AAEL013794 antibody, CpipJ_CPIJ001208 antibody, CpipJ_CPIJ001209 antibody, AIRE antibody, Aire antibody
- Background
- Synonyms:AIRE, AIRE1, APECED, APECED protein, APS1, APSI, autoimmune regulator, PGA1 Background:Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment, the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes(By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
- Molecular Weight
- 60kDa
- Gene ID
- 326
- UniProt
- O43918
- Pathways
- Chromatin Binding
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