AKR1C4 antibody

Catalog No. ABIN5696903

Product Details anti-AKR1C4 Antibody

Target: AKR1C4 (Aldo-keto Reductase Family 1 Member C4 (AKR1C4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKR1C4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Immunogen: aldo-keto reductase family 1, member C4 (chlordecone reductase, 3-alpha hydroxysteroid dehydrogenase, type I, dihydrodiol dehydrogenase 4)

Isotype: IgG

Application Details

Application Notes: WB :1:1000-1:10000,IF:1:10-1:100

Comment:

MCF7 cells were subjected to SDS PAGE followed by western blot with FNab00263(AKR1C4 antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for AKR1C4

Target: AKR1C4 (Aldo-keto Reductase Family 1 Member C4 (AKR1C4))

Alternative Name: AKR1C4 (AKR1C4 Products)

Synonyms: 3-alpha-HSD antibody, C11 antibody, CDR antibody, CHDR antibody, DD-4 antibody, DD4 antibody, HAKRA antibody, aldo-keto reductase family 1 member C4 antibody, AKR1C4 antibody

Background: Synonyms:AKR1C4, HAKRA, CHDR, 3 alpha HSD1, Chlordecone reductase Background:Catalyzes the transformation of the potent androgen dihydrotestosterone(DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol(3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone(kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

Molecular Weight: 37kDa

Gene ID: 1109

UniProt: P17516

Pathways: Steroid Hormone Biosynthesis