JAML antibody
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- Target See all JAML (AMICA1) Antibodies
- JAML (AMICA1) (Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This JAML antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Immunogen
- adhesion molecule, interacts with CXADR antigen 1
- Isotype
- IgG
- Top Product
- Discover our top product AMICA1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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HL-60 cells were subjected to SDS PAGE followed by western blot with FNab04436(AMICA1 antibody) at dilution of 1:800
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- JAML (AMICA1) (Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1))
- Alternative Name
- JAML (AMICA1 Products)
- Synonyms
- RGD1562572 antibody, AMICA antibody, CREA7-1 antibody, CREA7-4 antibody, Gm638 antibody, JAML antibody, Crea7 antibody, junction adhesion molecule like antibody, Jaml antibody, JAML antibody
- Background
- Synonyms:AMICA1 Background:Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
- Molecular Weight
- 30 kDa,44 kDa,50-60 kDa
- Gene ID
- 120425
- UniProt
- Q86YT9
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