BAFF antibody

Catalog No. ABIN5697275

Product Details anti-BAFF Antibody

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAFF antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: tumor necrosis factor (ligand) superfamily, member 13b

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for BAFF

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Alternative Name: TNFSF13B (TNFSF13B Products)

Synonyms: BAFF antibody, BLYS antibody, CD257 antibody, DTL antibody, TALL-1 antibody, TALL1 antibody, THANK antibody, TNFSF20 antibody, ZTNF4 antibody, BAFF-R antibody, BAFFR antibody, BROMIX antibody, CD268 antibody, CVID4 antibody, prolixin antibody, TNFSF13B antibody, RGD1561519 antibody, RGD1560810 antibody, BLyS antibody, D8Ertd387e antibody, zTNF4 antibody, 2010006P15Rik antibody, Baffr antibody, Bcmd antibody, Bcmd-1 antibody, Bcmd1 antibody, Lvis22 antibody, zgc:172115 antibody, TNF superfamily member 13b antibody, TNF receptor superfamily member 13C antibody, tumor necrosis factor (ligand) superfamily, member 13b antibody, tumor necrosis factor receptor superfamily, member 13c antibody, tumor necrosis factor superfamily member 13b antibody, TNFSF13B antibody, TNFRSF13C antibody, Tnfsf13b antibody, Tnfrsf13c antibody, tnfsf13b antibody

Background: Synonyms:BAFF, BLYS, TALL1, TNFSF20, ZTNF4 Background:Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands-2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor(BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

Gene ID: 10673

UniProt: Q9Y275

Pathways: NF-kappaB Signaling, Production of Molecular Mediator of Immune Response