NCK1 antibody
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- Target See all NCK1 Antibodies
- NCK1 (NCK Adaptor Protein 1 (NCK1))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NCK1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP)
- Immunogen
- NCK adaptor protein 1
- Isotype
- IgG
- Top Product
- Discover our top product NCK1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05583(NCK1 antibody) at dilution of 1:400
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- NCK1 (NCK Adaptor Protein 1 (NCK1))
- Alternative Name
- NCK1 (NCK1 Products)
- Synonyms
- NCK antibody, NCKalpha antibody, nck-1 antibody, NCK1 antibody, 6330586M15Rik antibody, D230010O13Rik antibody, Nck antibody, Nck-1 antibody, Nck1 antibody, nck antibody, nck1-a antibody, nck1-b antibody, nckalpha antibody, NCK adaptor protein 1 antibody, non-catalytic region of tyrosine kinase adaptor protein 1 antibody, NCK adaptor protein 1b antibody, NCK adaptor protein 1 L homeolog antibody, NCK1 antibody, Nck1 antibody, nck1b antibody, nck1.L antibody
- Background
- Synonyms:NCK Background:Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
- Molecular Weight
- 43 kDa
- Gene ID
- 4690
- UniProt
- P16333
- Pathways
- TCR Signaling, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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