HIC1 antibody
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- Target See all HIC1 Antibodies
- HIC1 (Hypermethylated in Cancer 1 (HIC1))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HIC1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- hypermethylated in cancer 1
- Isotype
- IgG
- Top Product
- Discover our top product HIC1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03857( HIC1 Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- HIC1 (Hypermethylated in Cancer 1 (HIC1))
- Alternative Name
- HIC1 (HIC1 Products)
- Synonyms
- zfHIC1 antibody, HIC1 antibody, ZBTB29 antibody, ZNF901 antibody, hic-1 antibody, AA408311 antibody, HIC-1 antibody, hypermethylated in cancer 1 antibody, HIC ZBTB transcriptional repressor 1 antibody, hic1 antibody, HIC1 antibody, Hic1 antibody
- Background
- Synonyms:ZBTB29 Background:Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1(indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
- Molecular Weight
- 65-70 kDa
- Gene ID
- 3090
- UniProt
- Q14526
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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