TNPO2 antibody

Catalog No. ABIN5698048

Product Details anti-TNPO2 Antibody

Target: TNPO2 (Transportin 2 (TNPO2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNPO2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Immunogen: transportin 2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for TNPO2

Target: TNPO2 (Transportin 2 (TNPO2))

Alternative Name: TNPO2 (TNPO2 Products)

Synonyms: TNPO2 antibody, IPO3 antibody, KPNB2B antibody, TRN2 antibody, ik:tdsubc_2a7 antibody, tdsubc_2a7 antibody, wu:fb01c02 antibody, wu:fe01f03 antibody, wu:fe16e12 antibody, xx:tdsubc_2a7 antibody, zgc:101009 antibody, 1110034O24Rik antibody, AA414969 antibody, AI464345 antibody, AI852433 antibody, Knpb2b antibody, Kpnb2b antibody, transportin 2 antibody, transportin 2 L homeolog antibody, transportin 2 (importin 3, karyopherin beta 2b) antibody, TNPO2 antibody, tnpo2.L antibody, Tnpo2 antibody, tnpo2 antibody

Background: Synonyms: Background:Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex(NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus(By similarity).

Gene ID: 30000

UniProt: O14787