ABL2 antibody
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- Target See all ABL2 Antibodies
- ABL2
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ABL2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogen
- v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
- Isotype
- IgG
- Top Product
- Discover our top product ABL2 Primary Antibody
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- Application Notes
- WB :1:500-1:5000,IHC:1:20-1:200,IF:1:10-1:100,IP:1:200-1:2000
- Comment
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab00053(ABL2 antibody) at dilution of 1:500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- ABL2
- Alternative Name
- ABL2 (ABL2 Products)
- Synonyms
- ABLL antibody, ARG antibody, Abll antibody, Arg antibody, AA536808 antibody, ABL proto-oncogene 2, non-receptor tyrosine kinase antibody, v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) antibody, ABL2 antibody, Abl2 antibody
- Background
- Synonyms:Abelson related gene protein, ABL2, ABLL, ARG, FLJ22224, FLJ31718, FLJ41441, Tyrosine protein kinase ABL2, Tyrosine protein kinase ARG Background:Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10(involved in movement), CTTN(involved in signaling), or TUBA1 and TUBB(microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
- Molecular Weight
- 127kDa
- Gene ID
- 27
- UniProt
- P42684
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