TAO Kinase 2 antibody

Catalog No. ABIN5699372

Product Details anti-TAO Kinase 2 Antibody

Target: TAO Kinase 2 (TAOK2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAO Kinase 2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Immunogen: TAO kinase 2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for TAO Kinase 2

Target: TAO Kinase 2 (TAOK2)

Alternative Name: TAOK2 (TAOK2 Products)

Synonyms: MAP3K17 antibody, PSK antibody, PSK1 antibody, PSK1-BETA antibody, TAO1 antibody, TAO2 antibody, Tao2 antibody, 1110033K02Rik antibody, B230344N16 antibody, mKIAA0881 antibody, TAOK2 antibody, map3k17 antibody, psk antibody, psk1 antibody, tao1 antibody, tao2 antibody, TAO kinase 2 antibody, TAO kinase 2 L homeolog antibody, serine/threonine-protein kinase TAO2 antibody, TAOK2 antibody, Taok2 antibody, taok2.L antibody, taok2 antibody, LOC100085396 antibody

Background: Synonyms:KIAA0881, MAP3K17, PSK, PSK1 Background:Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.

Gene ID: 9344

UniProt: Q9UL54

Pathways: Cell-Cell Junction Organization