APOBEC3C antibody
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- Target See all APOBEC3C Antibodies
- APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APOBEC3C antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
- Isotype
- IgG
- Top Product
- Discover our top product APOBEC3C Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Human peripheral blood leukocyte cells were subjected to SDS PAGE followed by western blot with FNab00494( APOBEC3C Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
- Alternative Name
- APOBEC3C (APOBEC3C Products)
- Synonyms
- APOBEC3C antibody, A3C antibody, APOBEC1L antibody, ARDC2 antibody, ARDC4 antibody, ARP5 antibody, PBI antibody, bK150C2.3 antibody, apolipoprotein B mRNA editing enzyme catalytic subunit 3C antibody, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C antibody, APOBEC3C antibody
- Background
- Synonyms:APOBEC1L, PBI Background:DNA deaminase(cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus(SIV), hepatitis B virus(HBV), herpes simplex virus 1(HHV-1) and Epstein-Barr virus(EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
- Molecular Weight
- 23 kDa
- Gene ID
- 27350
- UniProt
- Q9NRW3
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