DOC2B antibody

Catalog No. ABIN5700796

Product Details anti-DOC2B Antibody

Target: DOC2B (Double C2-Like Domains, beta (DOC2B))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOC2B antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Immunogen: double C2-like domains, beta

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for DOC2B

Target: DOC2B (Double C2-Like Domains, beta (DOC2B))

Alternative Name: DOC2B (DOC2B Products)

Synonyms: DOC2BL antibody, multiple C2 and transmembrane domain-containing protein 1-like antibody, double C2 domain beta antibody, double C2-like domains, beta antibody, double C2, beta antibody, LOC100369196 antibody, DOC2B antibody, doc2b antibody, Doc2b antibody

Background: Synonyms:DOC2BL Background:Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes(By similarity).

Molecular Weight: 46 kDa

Gene ID: 8447

UniProt: Q14184

Pathways: Positive Regulation of Peptide Hormone Secretion