SMC6 antibody

Catalog No. ABIN5701291

Product Details anti-SMC6 Antibody

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: structural maintenance of chromosomes 6

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for SMC6

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Alternative Name: SMC6 (SMC6 Products)

Synonyms: SMC6L1 antibody, SMC-6 antibody, hSMC6 antibody, 2810489L22Rik antibody, 3830418C19Rik antibody, AA990493 antibody, AU018782 antibody, AW742439 antibody, Smc6l1 antibody, mKIAA4103 antibody, structural maintenance of chromosomes 6 antibody, SMC6 antibody, smc6 antibody, Smc6 antibody

Background: Synonyms:SMC6L1 Background:Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).

Gene ID: 79677

UniProt: Q96SB8