SNAPIN antibody
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- Target See all SNAPIN Antibodies
- SNAPIN (SNAP-Associated Protein (SNAPIN))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SNAPIN antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)
- Immunogen
- SNAP-associated protein
- Isotype
- IgG
- Top Product
- Discover our top product SNAPIN Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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rat brain tissue were subjected to SDS PAGE followed by western blot with FNab08060( SNAPIN Antibody) at dilution of 1:200
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- SNAPIN (SNAP-Associated Protein (SNAPIN))
- Alternative Name
- SNAPIN (SNAPIN Products)
- Synonyms
- SNAPAP antibody, si:dkey-222b8.2 antibody, SNAPIN antibody, BLOC1S7 antibody, BLOS7 antibody, 25kDa antibody, AA407989 antibody, AV026596 antibody, Bloc1s7 antibody, Snap25bp antibody, Snapap antibody, SNAP associated protein antibody, SNAP-associated protein L homeolog antibody, SNAP-associated protein antibody, SNAPIN antibody, snapin.L antibody, snapin antibody, Snapin antibody
- Background
- Synonyms:BLOC1S7, SNAP25BP, SNAPAP Background:Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles(LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells(PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor(PubMed:25898167).
- Gene ID
- 23557
- UniProt
- O95295
- Pathways
- Synaptic Membrane, Synaptic Vesicle Exocytosis
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