KCNAB1 antibody
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- Target See all KCNAB1 Antibodies
- KCNAB1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 1 (KCNAB1))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KCNAB1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Immunogen
- potassium voltage-gated channel, shaker-related subfamily, beta member 1
- Isotype
- IgG
- Top Product
- Discover our top product KCNAB1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab04478(KCNAB1 antibody) at dilution of 1:1500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- KCNAB1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 1 (KCNAB1))
- Alternative Name
- KCNAB1 (KCNAB1 Products)
- Synonyms
- KCNAB1 antibody, zgc:113627 antibody, AKR6A3 antibody, KCNA1B antibody, KV-BETA-1 antibody, Kvb1.3 antibody, hKvBeta3 antibody, hKvb3 antibody, Kvbeta1.1 antibody, KVBETA1 antibody, Kv-beta-1 antibody, Akr8a8 antibody, mKv(beta)1 antibody, KvBeta3 antibody, potassium voltage-gated channel subfamily A member regulatory beta subunit 1 antibody, potassium voltage-gated channel, shaker-related subfamily, beta member 1 a antibody, potassium voltage-gated channel, shaker-related subfamily, beta member 1 antibody, KCNAB1 antibody, kcnab1a antibody, Kcnab1 antibody
- Background
- Synonyms:KCNA1B Background:Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits(PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits(By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity(By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members(PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels(PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure(PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4(PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6(By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1(PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity(By similarity). Binds NADPH, this is required for efficient down-regulation of potassium channel activity(PubMed:17540341). Has NADPH-dependent aldoketoreductase activity(By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity(By similarity).
- Molecular Weight
- 68 kDa
- Gene ID
- 7881
- UniProt
- Q14722
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