HMHA1 antibody
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- Target See all HMHA1 Antibodies
- HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HMHA1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- histocompatibility (minor) HA-1
- Isotype
- IgG
- Top Product
- Discover our top product HMHA1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03935(HMHA1 antibody) at dilution of 1:800
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))
- Alternative Name
- HMHA1 (HMHA1 Products)
- Synonyms
- RGD1308662 antibody, MGC80108 antibody, hmha1 antibody, arhgap45 antibody, ha-1 antibody, HMHA1 antibody, DKFZp469A2018 antibody, ARHGAP45 antibody, HA-1 antibody, HLA-HA1 antibody, 6330406L22Rik antibody, AW539505 antibody, Ha-1 antibody, Rho GTPase activating protein 45 antibody, Rho GTPase activating protein 45 L homeolog antibody, histocompatibility (minor) HA-1 b antibody, Arhgap45 antibody, ARHGAP45 antibody, arhgap45.L antibody, hmha1b antibody, arhgap45 antibody
- Background
- Synonyms:KIAA0223 Background:GTPase activator for the Rho-type GTPases. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens(mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease(GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation(BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte(CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
- Molecular Weight
- 140-150 kDa
- Gene ID
- 23526
- UniProt
- Q92619
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