HNRNPC antibody
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- Target See all HNRNPC Antibodies
- HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HNRNPC antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
- Immunogen
- heterogeneous nuclear ribonucleoprotein C (C1/C2)
- Isotype
- IgG
- Top Product
- Discover our top product HNRNPC Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab03949(HNRNPC antibody) at dilution of 1:500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))
- Alternative Name
- HNRNPC (HNRNPC Products)
- Synonyms
- C1 antibody, C2 antibody, HNRNP antibody, HNRPC antibody, SNRPC antibody, MGC53243 antibody, HNRNPC antibody, bZ1G18.4 antibody, fb57h12 antibody, fi16b11 antibody, wu:fb57h12 antibody, wu:fi16b11 antibody, zgc:55701 antibody, AL022939 antibody, D14Wsu171e antibody, Hnrpc antibody, Hnrpc1 antibody, Hnrpc2 antibody, hnRNPC1 antibody, hnRNPC2 antibody, hnrnp-C antibody, hnRNP C antibody, hnrnp antibody, hnrpc antibody, snrpc antibody, heterogeneous nuclear ribonucleoprotein C (C1/C2) antibody, heterogeneous nuclear ribonucleoprotein C (C1/C2) S homeolog antibody, heterogeneous nuclear ribonucleoprotein C antibody, heterogeneous nuclear ribonucleoprotein C (C1/C2) L homeolog antibody, HNRNPC antibody, hnrnpc.S antibody, hnrnpc antibody, Hnrnpc antibody, hnrnpc.L antibody
- Background
- Synonyms:HNRPC Background:Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles(PubMed:8264621). Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs(lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing(PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules(PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).
- Molecular Weight
- 32 kDa
- Gene ID
- 3183
- UniProt
- P07910
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