KPNA2 antibody

Catalog No. ABIN5703037

Product Details anti-KPNA2 Antibody

Target: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Immunogen: karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04635(KPNA2 antibody) at dilution of 1:1000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for KPNA2

Target: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Alternative Name: KPNA2 (KPNA2 Products)

Synonyms: IPOA1 antibody, QIP2 antibody, RCH1 antibody, SRP1alpha antibody, ima2 antibody, importin antibody, 2410044B12Rik antibody, PTAC58 antibody, Rch1 antibody, ipoa1 antibody, kpna2 antibody, qip2 antibody, rch1 antibody, srp1alpha antibody, hm:zeh0389 antibody, hm:zeh0389r antibody, zgc:113902 antibody, zgc:86945 antibody, karyopherin subunit alpha 2 antibody, importin subunit alpha-2 antibody, Importin subunit alpha-2 antibody, karyopherin (importin) alpha 2 antibody, karyopherin alpha-2 subunit like L homeolog antibody, karyopherin alpha 2 (RAG cohort 1, importin alpha 1) antibody, KPNA2 antibody, EDI_246290 antibody, EDI_335040 antibody, ima2 antibody, Kpna2 antibody, kpna2.L antibody, kpna2 antibody

Background: Synonyms:RCH1, SRP1 Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex(NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and-beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.

Molecular Weight: 55-58 kDa

Gene ID: 3838

UniProt: P52292

Pathways: M Phase, Protein targeting to Nucleus