GEMIN5 antibody
-
- Target See all GEMIN5 Antibodies
- GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This GEMIN5 antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Immunogen
- gem (nuclear organelle) associated protein 5
- Isotype
- IgG
- Top Product
- Discover our top product GEMIN5 Primary Antibody
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
-
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03420( GEMIN5 Antibody) at dilution of 1:1500
- Restrictions
- For Research Use only
-
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
-
- Target
- GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))
- Alternative Name
- GEMIN5 (GEMIN5 Products)
- Synonyms
- GEMIN-5 antibody, AA407055 antibody, AA407208 antibody, AI451603 antibody, BB194447 antibody, C330013N08 antibody, gem nuclear organelle associated protein 5 antibody, gem (nuclear organelle) associated protein 5 antibody, GEMIN5 antibody, Gemin5 antibody
- Background
- Synonyms: Background:The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins(snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.
- Molecular Weight
- 168 kDa
- Gene ID
- 25929
- UniProt
- Q8TEQ6
- Pathways
- Ribonucleoprotein Complex Subunit Organization
-