SNAIL antibody

Catalog No. ABIN5704381

Product Details anti-SNAIL Antibody

Target: SNAIL (SNAI1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: snail homolog 1 (Drosophila)

Isotype: IgG

Application Details

Application Notes: WB : 1:500-1:5000 IHC : 1:50-1:500

Comment:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab08051(SNAI1 antibody) at dilution of 1:1000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1 (SNAI1 Products)

Synonyms: SLUGH2 antibody, SNA antibody, SNAH antibody, SNAIL antibody, SNAIL1 antibody, dJ710H13.1 antibody, AI194338 antibody, Sna antibody, Sna1 antibody, Snail antibody, Snail1 antibody, SNAI1 antibody, BG:DS01845.1 antibody, CG3956 antibody, Dmel\\CG3956 antibody, Sco antibody, br28 antibody, br29 antibody, l(2)35Db antibody, l(2)br28 antibody, l(2)br29 antibody, l(3)br28 antibody, l35Db antibody, sn antibody, Xsnail antibody, sna antibody, snail1 antibody, xSna antibody, Snai antibody, sna2 antibody, snail2 antibody, cb643 antibody, sna-1 antibody, sna1 antibody, snai1 antibody, snail1a antibody, zgc:109820 antibody, snail family transcriptional repressor 1 antibody, snail family zinc finger 1 antibody, snail homolog 1 (Drosophila) antibody, snail antibody, zinc-finger transcription factor Snail antibody, snail family zinc finger 1 S homeolog antibody, protein escargot antibody, transcription factor protein antibody, snail zinc finger protein antibody, snail family zinc finger 1b antibody, snail family zinc finger 1a antibody, SNAI1 antibody, Snai1 antibody, sna antibody, snail antibody, snai1.S antibody, LOC410464 antibody, snai1b antibody, snai1a antibody

Background: Synonyms:Protein sna, Protein snail homolog 1, SLUGH2, SNA, SNAH, SNAI1, snail homolog 1(Drosophila), SNAIL1, Zinc finger protein SNAI1 Background:Involved in induction of the epithelial to mesenchymal transition(EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate(TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Molecular Weight: 29KD

Gene ID: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling