PMEPA1 antibody

Catalog No. ABIN5704584

Product Details anti-PMEPA1 Antibody

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMEPA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Immunogen: prostate transmembrane protein, androgen induced 1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

L02 cells were subjected to SDS PAGE followed by western blot with FNab06569( PMEPA1 Antibody) at dilution of 1:600

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for PMEPA1

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Alternative Name: PMEPA1 (PMEPA1 Products)

Synonyms: Tmepai antibody, PMEPA1 antibody, TMEPAI antibody, zgc:92731 antibody, tmepai antibody, STAG1 antibody, 2210418I02Rik antibody, AW455466 antibody, Erg1.2 antibody, N4wbp4 antibody, Stag1 antibody, prostate transmembrane protein, androgen induced 1 antibody, prostate transmembrane protein, androgen induced 1 L homeolog antibody, Pmepa1 antibody, PMEPA1 antibody, pmepa1 antibody, pmepa1.L antibody

Background: Synonyms:STAG1, TMEPAI Background:Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal(PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor(AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4(PubMed:18703514).

Gene ID: 56937

UniProt: Q969W9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway