SRGAP2 antibody

Catalog No. ABIN5704861

Product Details anti-SRGAP2 Antibody

Target: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRGAP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: SLIT-ROBO Rho GTPase activating protein 2

Isotype: IgG

Application Details

Application Notes: WB : 1:500-1:5000 IP : 1:500-1:5000 IHC : 1:20-1:200

Comment:

mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab08225(SRGAP2 antibody) at dilution of 1:1000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for SRGAP2

Target: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Alternative Name: SRGAP2 (SRGAP2 Products)

Synonyms: ARHGAP34 antibody, FNBP2 antibody, SRGAP2A antibody, SRGAP3 antibody, 9930124L22Rik antibody, AI448945 antibody, FBP2 antibody, Fnbp2 antibody, srGAP3 antibody, AI452337 antibody, Arhgap14 antibody, D130026O08Rik antibody, Gbi antibody, MEGAP antibody, WRP antibody, mKIAA0411 antibody, RGD1566016 antibody, srGAP2 antibody, srgap2a antibody, wu:fb47h12 antibody, zgc:136814 antibody, fnbp2 antibody, srgap2 antibody, SLIT-ROBO Rho GTPase activating protein 2 antibody, SLIT-ROBO Rho GTPase activating protein 3 antibody, SLIT-ROBO Rho GTPase activating protein 2 L homeolog antibody, SRGAP2 antibody, Srgap2 antibody, Srgap3 antibody, srgap2 antibody, srgap2.L antibody

Background: Synonyms:ARHGAP34, FNBP2, Formin binding protein 2, KIAA0456, SRGAP2, srGAP3 Background:RAC1 GTPase activating protein(GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

Molecular Weight: 130 kDa

Gene ID: 23380

UniProt: O75044