NHP2 antibody

Catalog No. ABIN5705393

Product Details anti-NHP2 Antibody

Target: NHP2 (NHP2 Ribonucleoprotein (NHP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NHP2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunogen: NHP2 ribonucleoprotein homolog (yeast)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

A375 cells were subjected to SDS PAGE followed by western blot with FNab05727(NHP2 antibody) at dilution of 1:300

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for NHP2

Target: NHP2 (NHP2 Ribonucleoprotein (NHP2))

Alternative Name: NHP2 (NHP2 Products)

Synonyms: DKCB2 antibody, NHP2P antibody, NOLA2 antibody, 2410130M07Rik antibody, D11Ertd175e antibody, Nola2 antibody, NHP2 ribonucleoprotein antibody, NHP2 antibody, Nhp2 antibody

Background: Synonyms:NHP2, NHP2P, NOLA2, snoRNP protein NHP2 Background:Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein(H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase(TERT) holoenzyme.

Molecular Weight: 17-20 kDa

Gene ID: 55651

UniProt: Q9NX24

Pathways: Telomere Maintenance