CCDC22 antibody

Catalog No. ABIN5705501

Product Details anti-CCDC22 Antibody

Target: CCDC22 (Coiled-Coil Domain Containing 22 (CCDC22))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC22 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: coiled-coil domain containing 22

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for CCDC22

Target: CCDC22 (Coiled-Coil Domain Containing 22 (CCDC22))

Alternative Name: CCDC22 (CCDC22 Products)

Synonyms: CXorf37 antibody, AI481216 antibody, DXImx40e antibody, Ppp1r3f antibody, Sfc22 antibody, RGD1560910 antibody, zgc:114058 antibody, coiled-coil domain containing 22 antibody, CCDC22 antibody, Ccdc22 antibody, ccdc22 antibody

Background: Synonyms:CXorf37 Background:Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation, the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via assocation with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10(PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes(PubMed:25355947).

Molecular Weight: 71 kDa

Gene ID: 28952

UniProt: O60826