POLR1A antibody

Catalog No. ABIN5705943

Product Details anti-POLR1A Antibody

Target: POLR1A (Polymerase (RNA) I Polypeptide A, 194kDa (POLR1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLR1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: polymerase (RNA) I polypeptide A, 194kDa

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for POLR1A

Target: POLR1A (Polymerase (RNA) I Polypeptide A, 194kDa (POLR1A))

Alternative Name: POLR1A (POLR1A Products)

Synonyms: 194kDa antibody, 3010014K16Rik antibody, RPA194 antibody, Rpo1-4 antibody, mRPA1 antibody, Rpa1 antibody, A190 antibody, RPA1 antibody, RPO1-4 antibody, RPO14 antibody, polymerase (RNA) I polypeptide A antibody, RNA polymerase I subunit A antibody, Polr1a antibody, POLR1A antibody

Background: Synonyms:A190, POLR1A, RNA polymerase I subunit A1, RPA1, RPA194, RPO1 4 Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition(By similarity).

Gene ID: 25885

UniProt: O95602