NPC1 antibody (AA 1022-1278)

Catalog No. ABIN5708097

Product Details anti-NPC1 Antibody

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Binding Specificity: AA 1022-1278

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPC1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Antigen affinity purified

Immunogen: A human partial recombinant protein corresponding to amino acids A1022-F1278 was used as the immunogen for the NPC1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NPC1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Direct ELISA: 0.1-0.5 μg/mL (recombinant human protein) (BSA-free format available)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the NPC1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for NPC1

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Alternative Name: Niemann Pick C1 (NPC1 Products)

Synonyms: NPC antibody, 9130221N23Rik antibody, Gm243 antibody, Cdig2 antibody, im:7149020 antibody, wu:fb53a12 antibody, wu:fc29a12 antibody, A430089E03Rik antibody, C85354 antibody, D18Ertd139e antibody, D18Ertd723e antibody, lcsd antibody, nmf164 antibody, spm antibody, NPC intracellular cholesterol transporter 1 antibody, NPC1 like intracellular cholesterol transporter 1 antibody, Niemann-Pick disease, type C1 antibody, Niemann-Pick C1 protein antibody, NPC1 antibody, Npc1l1 antibody, Npc1 antibody, npc1 antibody, LOC579887 antibody

Background: Niemann-Pick disease, type C1 (NPC1) is a membrane protein that mediates intracellular cholesterol trafficking in mammals. In humans it is encoded by the NPC1 gene (chromosome location 18q11). This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

UniProt: O15118