Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
AL024441,COX 4,COX IV 1,COX IV,COX IV-1,Cox4,COX41,Cox4a,COX4B,COX4I1,COX4I2,COX4L2,COXIV,Cytochrome c oxidase polypeptide IV,Cytochrome c oxidase subunit 4 isoform 1 mitochondrial,Cytochrome c oxidase subunit 4 isoform 1,mitochondrial,Cytochrome C Oxidase subunit IV,Cytochrome c oxidase subunit IV isoform 1,Cytochrome c oxidase subunit IV isoform 2 (lung),Cytochrome c oxydase subunit 4,dJ857M17.2,MGC105470,MGC72016
COX4 antibody, COX4-1 antibody, COXIV antibody, mg:bb02d03 antibody, zgc:110058 antibody, GB20012 antibody, AL024441 antibody, Cox4 antibody, Cox4a antibody, cox4 antibody, cox4i1 antibody, coxiv antibody, BcDNA:AT07685 antibody, CG10396 antibody, COX IV antibody, CX41 antibody, CX42 antibody, Dmel\CG10396 antibody, IV antibody, cytochrome c oxidase subunit 4I1 antibody, cytochrome c oxidase subunit IV isoform 1 antibody, cytochrome c oxidase subunit 4 isoform 1, mitochondrial antibody, cytochrome c oxidase polypeptide IV antibody, cytochrome c oxidase subunit IV antibody, cytochrome c oxidase subunit 4i1 antibody, cytochrome c oxidase subunit IV isoform 1 S homeolog antibody, Cytochrome c oxidase subunit 4-like antibody, COX4I1 antibody, cox4i1 antibody, LOC412396 antibody, Cox4I1 antibody, LOC780848 antibody, BMEII0322 antibody, RSal33209_1582 antibody, SJAG_00976 antibody, HMPREF0733_11926 antibody, Cox4i1 antibody, cox4i1.S antibody, COX4L antibody
Background
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.