Caspase 10 B/C antibody

Catalog No. ABIN5956727

Product Details

Target: Caspase 10 B/C

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: ALPS2,apoptotic protease Mch-4,CASP-10,CASPA,caspase-10,FADD-like ICE2,FAS-associated death domain protein interleukin-1B-convert

Purification: Affinity purification

Immunogen: Synthesized peptide derived from the C-terminal region of human Caspase-10 B/C

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details

Target: Caspase 10 B/C

Alternative Name: Caspase-10 B/C

Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-AMC and Asp-Glu-Val-Asp-AMC.Isoform C is proteolytically inactive.

Molecular Weight: 59kDa

Gene ID: 843